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Wei et al. Page 14 Drug Discov Today. Author manuscript; available in PMC 2016 May 01. Antiviral effect of AgNPs Type Size (nm) Surface stability Microbial strains Function Refs AgNPs 1–10 Carbon, PVP and BSA HIV-1 Size-dependent interaction with HIV-1; inhibits virus from binding to host [55] cells AgNP@MHCs AgNPs Inactivates viral pathogens with minimum chance of potential release into [56] environment 10 and 25 10, 50, and 800 N/A None and polysaccharide None TCRV HBV RSV Inhibits viral replication [55] Only 10-nm AgNPs inhibit replication of HBV [55] 44% inhibition of syncytial virus [54] 10–80 11.2 None or polysaccharide-coated biogenic Ag0 (MPV) MNV-1 AgNPs of approximately 10 nm inhibit MPV infection in vitro [55] Addition of 31.25 mg biogenic Ag0 m−2 on the filter caused 3.8-log decline [55] 10 7, 15, and 30 None None H1N1 influenza A virus ΦX174, MNV, and AdV2 Rapidly inhibits H1N1 influenza A virus hemagglutination of chicken [55] RBCs 9.5 nm None None H3N2 influenza virus HSV-1, HSV-2, and HPIV-3 Prevents H3N2 influenza virus infection both in vitro and in vivo [57] AgNPs with a size of 4–13 nm and 5–23 nm, had better antiviral activity [58] 4–13, 5–23, and 7– 20 against HSV-1 and HPIV-3 viruses Inhibits vaccinia virus replication by preventing viral entry [59] 25 aAbbreviations: BSA: bovine serum albumin; N/A: not available.. VACV PVP- AgNPs, recombinant RSV fusion (F) protein and BSA None Table 1 of the virus compared with 1.5-log decrease by original filter Author Manuscript Author Manuscript Author Manuscript Author ManuscriptPDF Image | Silver nanoparticles: synthesis, properties, therapeutic apps
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