Hydrogel Forming Dressings Containing Silver Nanoparticles

PDF Publication Title:

Hydrogel Forming Dressings Containing Silver Nanoparticles ( hydrogel-forming-dressings-containing-silver-nanoparticles )

Next Page View | Return to Search List

Text from PDF Page: 001

􏰁􏰂􏰃 􏰅􏰆􏰇 􏰈􏰉􏰊􏰋􏰌􏰂􏰍 nanomaterials Article The Design, Characterization and Antibacterial Activity of Heat and Silver Crosslinked Poly(Vinyl Alcohol) Hydrogel Forming Dressings Containing Silver Nanoparticles John Jackson 1,*, Helen Burt 1, Dirk Lange 2, In Whang 1, Robin Evans 3 and David Plackett 1 Citation: Jackson, J.; Burt, H.; Lange, D.; Whang, I.; Evans, R.; Plackett, D. The Design, Characterization and Antibacterial Activity of Heat and Silver Crosslinked Poly(Vinyl Alcohol) Hydrogel Forming Dressings Containing Silver Nanoparticles. Nanomaterials 2021, 11, 96. https://doi.org/10.3390/ nano11010096 Received: 19 November 2020 Accepted: 29 December 2020 Published: 4 January 2021 Publisher’s Note: MDPI stays neu- tral with regard to jurisdictional clai- ms in published maps and institutio- nal affiliations. Copyright: © 2021 by the authors. Li- censee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and con- ditions of the Creative Commons At- tribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). 1 2 Abstract: The prompt treatment of burn wounds is essential but can be challenging in remote parts of Africa, where burns from open fires are a constant hazard for children and suitable medical care may be far away. Consequently, there is an unmet need for an economical burn wound dressing with a sustained antimicrobial activity that might be manufactured locally at low cost. This study describes and characterizes the novel preparation of a silver nitrate-loaded/poly(vinyl alcohol) (PVA) film. Using controlled heating cycles, films may be crosslinked with in situ silver nanoparticle production using only a low heat oven and little technical expertise. Our research demonstrated that heat-curing of PVA/silver nitrate films converted the silver to nanoparticles. These films swelled in water to form a robust, wound-compatible hydrogel which exhibited controlled release of the antibacterial silver nanoparticles. An optimal formulation was obtained using 5% (w/w) silver nitrate in PVA membrane films that had been heated at 140 ◦C for 90 min. Physical and chemical characterization of such films was complemented by in vitro studies that confirmed the effective antibacterial activity of the released silver nanoparticles against both gram positive and negative bacteria. Overall, these findings provide economical and simple methods to manufacture stable, hydrogel forming wound dressings that release antibiotic silver over prolonged periods suitable for emergency use in remote locations. Keywords: wound dressing; silver nanoparticles; PVA hydrogel; anti-infective 1. Introduction Traumatic burn wounds resulting from accidents associated with open fires used for heating and cooking are common in the rural areas of African countries. Children in particular suffer many such injuries and, in remote locations far from medical care, burn wounds can often lead to more complex care situations [1,2]. Commercial wound dressings are normally much too expensive to be used in most African settings. We therefore initiated a research project aimed at developing a package or kit that could be used for immediate treatment of burn wounds in remote African communities. Such kits might contain a dressing, a pictorial instruction manual for application of the dressing, a bottle of rehydration salts, and cell phone numbers for clinics or nurses. These kits might provide an important window of opportunity for the injured person to access proper hospital care before serious infection or abnormal healing might occur. The wound dressing, as the key component of the proposed burn survival kit, should provide an anti-infective comfortable wound covering for one week or more and be easily removable without trauma to the patient. UBC Faculty of Pharmaceutical Sciences, 2045 Wesbrook Mall, UBC, Vancouver, BC V6T1Z3, Canada; helen.burt@ubc.ca (H.B.); inwhang2010@gmail.com (I.W.); davidplackett@gmail.com (D.P.) Stone Centre, UBC Department of Urologic Sciences, Vancouver General Hospital, Vancouver, BC V6T1Z3, Canada; dirk.lange@stonecentrevgh.ca 3 robinjamesevans@gmail.com Plastic and Reconstructive Surgery Clinic, Ventura county medical clinic, Ventura, CA 93003, USA; * Correspondence: jackson@mail.ubc.ca Nanomaterials 2021, 11, 96. https://doi.org/10.3390/nano11010096 https://www.mdpi.com/journal/nanomaterials

PDF Image | Hydrogel Forming Dressings Containing Silver Nanoparticles


PDF Search Title:

Hydrogel Forming Dressings Containing Silver Nanoparticles

Original File Name Searched:


DIY PDF Search: Google It | Yahoo | Bing

Turbine and System Plans CAD CAM: Special for this month, any plans are $10,000 for complete Cad/Cam blueprints. License is for one build. Try before you buy a production license. More Info

Waste Heat Power Technology: Organic Rankine Cycle uses waste heat to make electricity, shaft horsepower and cooling. More Info

All Turbine and System Products: Infinity Turbine ORD systems, turbine generator sets, build plans and more to use your waste heat from 30C to 100C. More Info

CO2 Phase Change Demonstrator: CO2 goes supercritical at 30 C. This is a experimental platform which you can use to demonstrate phase change with low heat. Includes integration area for small CO2 turbine, static generator, and more. This can also be used for a GTL Gas to Liquids experimental platform. More Info

Introducing the Infinity Turbine Products Infinity Turbine develops and builds systems for making power from waste heat. It also is working on innovative strategies for storing, making, and deploying energy. More Info

Need Strategy? Use our Consulting and analyst services Infinity Turbine LLC is pleased to announce its consulting and analyst services. We have worked in the renewable energy industry as a researcher, developing sales and markets, along with may inventions and innovations. More Info

Made in USA with Global Energy Millennial Web Engine These pages were made with the Global Energy Web PDF Engine using Filemaker (Claris) software.

Infinity Turbine Developing Spinning Disc Reactor SDR or Spinning Disc Reactors reduce processing time for liquid production of Silver Nanoparticles.

CONTACT TEL: 608-238-6001 Email: greg@infinityturbine.com | RSS | AMP