PDF Publication Title:
Text from PDF Page: 036
SCCS/1596/18 Final Opinion on Colloidal Silver (nano) __________________________________________________________________________________________ 1.Mammalian cell chromosome aberration/clastogenicity – determined either by in vitro chromosome aberration test or micronucleus test. The micronucleus test can be performed by the mononucleate or cytokinesis blocked protocols. In the cytokinesis blocked micronucleus assay, co-exposure to both cytochalasin B and the test nanomaterial for the duration of the experiment is not considered acceptable. 2. An in vitro mammalian cell gene mutation test (e.g. hprt, tk or xprt tests). Other indicator tests, such as the Comet assay, may be included as a further weight of evidence. New in vitro approaches such as cell transformation assays or toxicogenomic approaches may also be useful for identification of genotoxic as well as non-genotoxic carcinogen nanomaterials. 3. In vitro genotoxicity studies should be accompanied by an assessment of cellular and nuclear uptake to demonstrate target exposure to enable a complete evaluation of data-outputs. (b) Where point 1 and 2 indicate significant systemic uptake (c) Where point 1 and 2 indicate significant systemic uptake and/or bioaccumulation Table 2B: Summary of toxicological data provided in the submission Typ Ref Phys- Acu e chem te data E 13-15 +(3/17) X Repe Geno Geno Cancer Repro ated tox tox tox dose bact other X X X Yes X Irrita Sensiti tion sation X Yes Ab Kinetic sorp s tion XX X X A, B, C, D, J, K, L 1-12 ++ * (11/17)** Yes, oral X X Yes Yes X Yes, skin, eye Yes F16-18+(4/17)Yes,XXXX X oral eye H 22-24 +(4/17) Yes, X X X X X oral I 25-27 ++ X X X X X X (11/17) *: +, ++, +++ is available **: number of parameters available (total is 17) X: study/ data not available, not provided Yes,eye X X X X Yes X X Yes,skin,YesXX X G 19-21 + (5/17) Yes, oral, derm al X Yes X X X Yes, skin, eye X X NB: For all toxicological data in the Table: these are statements without any experimental evidence. 36PDF Image | Consumer Safety SCCS OPINION ON Colloidal Silver (nano)
PDF Search Title:
Consumer Safety SCCS OPINION ON Colloidal Silver (nano)Original File Name Searched:
sccs_o_219.pdfDIY PDF Search: Google It | Yahoo | Bing
Turbine and System Plans CAD CAM: Special for this month, any plans are $10,000 for complete Cad/Cam blueprints. License is for one build. Try before you buy a production license. More Info
Waste Heat Power Technology: Organic Rankine Cycle uses waste heat to make electricity, shaft horsepower and cooling. More Info
All Turbine and System Products: Infinity Turbine ORD systems, turbine generator sets, build plans and more to use your waste heat from 30C to 100C. More Info
CO2 Phase Change Demonstrator: CO2 goes supercritical at 30 C. This is a experimental platform which you can use to demonstrate phase change with low heat. Includes integration area for small CO2 turbine, static generator, and more. This can also be used for a GTL Gas to Liquids experimental platform. More Info
Introducing the Infinity Turbine Products Infinity Turbine develops and builds systems for making power from waste heat. It also is working on innovative strategies for storing, making, and deploying energy. More Info
Need Strategy? Use our Consulting and analyst services Infinity Turbine LLC is pleased to announce its consulting and analyst services. We have worked in the renewable energy industry as a researcher, developing sales and markets, along with may inventions and innovations. More Info
Made in USA with Global Energy Millennial Web Engine These pages were made with the Global Energy Web PDF Engine using Filemaker (Claris) software.
Infinity Turbine Developing Spinning Disc Reactor SDR or Spinning Disc Reactors reduce processing time for liquid production of Silver Nanoparticles.
| CONTACT TEL: 608-238-6001 Email: greg@infinityturbine.com | RSS | AMP |