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SCCS/1596/18 Final Opinion on Colloidal Silver (nano) __________________________________________________________________________________________ 3.1.4. Purity, composition and substance codes Products are described as water dispersion (colloid) of silver nanoparticles with a concentration of (see also Table 2): 50 or 100 ppm (A, B, C, D, J, K, L) 1000 ppm (F,G) 0.015% (H) Additional information Ref.:1, 4, 7, 10, 43 Ref.: 16 Ref.: 22 The total concentration of colloidal silver Ag 100 (material I) was determined by Atomic absorption spectroscopy (AAS) and was found to be 35.3 μg/ml (ppm). The ionic silver concentration in colloidal silver Ag 100 was determined by a total dissolved solids (TDS) meter and was found to be 28.2 μg/ml (ppm). The concentration of colloidal silver nanoparticles was determined to be 35.3-28.2= 7.1 μg/ml (7.1 mg/l= 0.0071 g/l). The number of moles (colloidal silver per volume) = 3.96 x 1019 moles/l. Ref.: 53 SCCS comment: Purity and composition data were provided for all but one (E) colloidal silver dispersions. Additional, more detailed information has been submitted for dispersion I. These data are, however, required for all colloidal silver dispersions. 3.1.5. Impurities / accompanying contaminants According to the relevant Applicants, traces of heavy metals were quantified by a testing laboratory with satisfactory results (colloidal silver dispersion H, ref 22) and impurities endangering human health were not identified (colloidal silver dispersion I, ref 25). Ref.: 22, 25 Silver dispersions A, B, C, and D have been indicated by the Applicants to be Ag4N. Furthermore, it is stated that dispersion A has “a very high chemical purity”. Ref.: 3, 5, 11 For one of the colloidal silver dispersions (dispersion E), an analysis of constituents has been performed (see Table 3). Table 3: Analysis of colloidal silver dispersion (dispersion E) Method reference M_ICP-OES M_ICPMS C_COLOUR M_ICPMS M_ICPMS M_ICPMS C_COLOUR C_COND M_ICPMS C_ISE Test Test description Result Units PHOSPHTO_2 <0.070 mg/l ALUMINTO_2 AMMONIA ARSENITO_2 CADMIUTO_2 CALCIUTO_2 CHLORIDE COND_20C COPPERTO_2 Copper <5.50 ug/l F Fluoride <0.02 mg/l Aluminium 0.021 mg/l Ammonia <0.03 Arsenic <1.000 ug/l Cadmium <1.50 ug/l Calcium 0.37 mg/l Chloride <0.60 mg/l Conductivity 19 uS/cm mg/l as N 10PDF Image | Consumer Safety SCCS OPINION ON Colloidal Silver (nano)
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