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Nanomaterials 2020, 10, 390 13 of 16 Wistar rats highlighting that AgNPs can accelerate tissue formation and promote earlier development of primary collagen scars. Author Contributions: F.R.D., R.C.A.P.M., L.R., L.N.A., M.V.C., C.F.d.S., C.B.C., R.L.C.d.A.J., S.R.S., S.H. and L.P.d.C. have contributed to the methodology, formal analysis, investigation, resources, and data curation. F.R.D., R.C.A.P.M., L.R., L.N.A., M.V.C., C.F.d.S., C.B.C., R.L.C.d.A.J., S.R.S., S.H. and L.P.d.C. have contributed to the writing of the original manuscript. E.B.S., E.S.-L., L.N.A., M.V.C., and P.S. have contributed to the conceptualization, review and editing of the manuscript, project administration, supervision and funding acquisition. All authors have made a substantial contribution to the work and have approved its publication. All authors have read and agreed to the published version of the manuscript. Funding: This research received funding from the Coordenação Aperfeiçoamento de Pessoal de Nivel Superior (CAPES), Fundação de Amparo à Pesquisa do Estado de Sergipe (FAPITEC), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, #443238/2014-6, #470388/2014-5), and from the Portuguese Science and Technology Foundation (FCT) projects M-ERA-NET/0004/2015 (PAIRED) and UIDB/04469/2020 (strategic fund). Conflicts of Interest: The authors declare no conflict of interest. References 1. Winter, G.D. Formation of the scab and the rate of epithelisation of superficial wounds in the skin of the young domestic pig. 1962. Discussion. J. Wound Care 1995, 4, 366–367. 2. Winter, G.D. Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. Nature 1962, 193, 293–294. [CrossRef] [PubMed] 3. Maneerung, T.; Tokura, S.; Rujiravanit, R. Impregnation of silver nanoparticles into bacterial cellulose for antimicrobial wound dressing. Carbohydr. Polym. 2008, 72, 43–51. [CrossRef] 4. Salehi, B.; Venditti, A.; Sharifi-Rad, M.; Kregiel, D.; Sharifi-Rad, J.; Durazzo, A.; Lucarini, M.; Santini, A.; Souto, E.B.; Novellino, E.; et al. The Therapeutic Potential of Apigenin. Int. J. Mol. Sci. 2019, 20, 1305. [CrossRef] 5. Debone, H.S.; Lopes, P.S.; Severino, P.; Yoshida, C.M.P.; Souto, E.B.; da Silva, C.F. Chitosan/Copaiba oleoresin films for would dressing application. Int. J. Pharm. 2019, 555, 146–152. [CrossRef] 6. Acharya, C.; Panda, C.R.; Bhaskara, P.K.; Sasmal, A.; Shekhar, S.; Sen, A.K.J.P.B. Physicochemical and antimicrobial properties of sodium alginate/gelatin-based silver nanoformulations. Polym. Bull. 2017, 74, 689–706. [CrossRef] 7. Severino, P.; da Silva, C.F.; Andrade, L.N.; de Lima Oliveira, D.; Campos, J.; Souto, E.B. Alginate Nanoparticles for Drug Delivery and Targeting. Curr. Pharm. Des. 2019, 25, 1312–1334. [CrossRef] [PubMed] 8. Ilkar Erdagi, S.; Asabuwa Ngwabebhoh, F.; Yildiz, U. Genipin crosslinked gelatin-diosgenin-nanocellulose hydrogels for potential wound dressing and healing applications. Int. J. Biol. Macromol. 2020, 149, 651–663. [CrossRef] [PubMed] 9. Li, Y.; Jia, H.; Cheng, Q.; Pan, F.; Jiang, Z. Sodium alginate–gelatin polyelectrolyte complex membranes with both high water vapor permeance and high permselectivity. J. Membr. Sci. 2011, 375, 304–312. [CrossRef] 10. Peppas, N.A.; Bures, P.; Leobandung, W.; Ichikawa, H. Hydrogels in pharmaceutical formulations. Eur. J. Pharm. Biopharm. 2000, 50, 27–46. [CrossRef] 11. Ye, H.; Cheng, J.; Yu, K. In situ reduction of silver nanoparticles by gelatin to obtain porous silver nanoparticle/chitosan composites with enhanced antimicrobial and wound-healing activity. Int. J. Biol. Macromol. 2018, 121, 633–642. [CrossRef] [PubMed] 12. Sánchez-López, E.; Gomes, D.; Esteruelas, G.; Bonilla, L.; Lopez-Machado, A.L.; Galindo, R.; Cano, A.; Espina, M.; Ettcheto, M.; Camins, A.; et al. Metal-Based Nanoparticles as Antimicrobial Agents: An Overview. Nanomaterials 2020, 10, 292. [CrossRef] [PubMed] 13. Ashour, A.A.; Raafat, D.; El-Gowelli, H.M.; El-Kamel, A.H. Green synthesis of silver nanoparticles using cranberry powder aqueous extract: characterization and antimicrobial properties. Int. J. Nanomed. 2015, 10, 7207–7221. 14. Iravani, S.; Korbekandi, H.; Mirmohammadi, S.; Zolfaghari, B. Synthesis of silver nanoparticles: Chemical, physical and biological methods. Res. Pharm. Sci. 2014, 9, 385–406.PDF Image | Wound Healing Silver Nanoparticles-Composing Hydrogel
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