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Table 1: IC50 values at 24 h of Ag-NPs-EPS in selected cancer cell lines IC50 (μg/ml) ± SD AgNPs-EPSanaer AgNPs-EPSaer Metal free-EPS SKBR3 50 ± 1.5 5 ± 0.5 NA 8701-BC 75 ± 1.3 8.2 ± 0.8 NA HT29 NA 20 ± 2 NA HCT116 NA 26 ± 2 NA CaCo2 NA 34 ± 4 NA Table 2: IC50 values calculated at 24 and 48 h of AgNPs-EPSaer treatment, in SKBR3 breast cancer cell line and in the non tumoral epithelial mammary cell line HB2 HB2 IC50 ± SD SKBR3 IC50 ± SD Selectivity index SI (HB2IC50/SKBR3 IC50) AgNPsaer Doxorubicin 24 h 17 ± 0.5a 15.8 ± 2,1b 48 h 9 ± 0.8a 5.3 ± 1b 24 h 5 ± 0.5a 4.1 ± 0.5b 48 h 1.8 ± 0.8a 1.12 ± 0.1b 24 h 3.4 3.8 48 h 5 4.8 SI was calculated as ratio between AgNPs-EPSaer IC50 values obtained for HB2 and SKBR3. aValues expressed as μg/ml; bvalues expressed as μM. after 1 h-treatment. On the other hand, AgNPs-EPSanaer treatment inhibited cell proliferation in a dose- and time- dependent manner only at the highest dose of 50 μg/ml. Thus, according MTT assay results, AgNPs-EPSaer exerts a superior biocide activity in comparison to AgNPs-EPSanaer. None effect was observed for free-metal EPS. AgNPs-EPS inhibit motility and MMPs activity in SKBR3 cells Migration and invasion represent a cancer progression hallmark [31], so we tested the effect of Ag-NPs-EPS on cell motility by performing a wound- Figure 1: Cytotoxic effect of AgNPs-EPS in SKBR3 cells evaluated by clonogenic assay. (A) Culture dishes with stained colonies of a representative experiment; (B) Statistical results of colony-forming assays presented as percentage of colonies numbers in the respect of untreated cells used as control. Statistical significance was assessed by the Student’s t-test: *p < 0.05 was considered significant; ***p < 0.001 very highly significant. The data in the graphs are expressed as mean number ± SD of three different experiments. www.impactjournals.com/oncotarget 9687 OncotargetPDF Image | Anticancer activity of biogenerated silver nanoparticles
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